Microcrystalline Cellulose as Pharmaceutical Excipient Material safety data sheet - FMC Corporation. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Performing this action will revert the following features to their default settings: Hooray! stream ( Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. There may be more fiber in your food than you realized. If you are already a ChemPoint customer then sign up for access to our online ordering website. AVICEL RC 581. Truly distinctive drug delivery solutions. MATERIAL SAFETY DATA SHEET - Sevron JFIF ` ` ZExif MM * J Q Q Q C >> Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Apply today! endobj Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Watch Now. Powder becomes slippery when wet. SUBSTANCE IDENTIFICATION 1.1. endobj With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. 102331. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Cellulose microcrystalline CAS 9004-34-6 | 102331 - EMD Millipore GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Synonyms: Cellulose, Cellulose powder, Cotton linters. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Trademarks: Avicel PH-102. % They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. We are artists at heart and creators by nature. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. PDF Safety Data Sheet : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Instead, they obtained a stable colloidal suspension. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). gac74 [#B6`Wnw7 : 5. Fiber supplements can lessen the absorption of some . Millipore. Micro Crystalline Cellulose. endobj Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Magazine: Material safety data sheet - FMC Corporation. Origin(s): Plant/Botanical. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Revision No. Cellulose microcrystalline MSDS - 102331 - Merck Product Name: Microcrystalline Cellulose E460 1.2. The typical mean particle size is 20200 m. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. l~5C BIOACCUMULATIVE POTENTIAL Report Category. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Earth Supplied Products LLC. It . 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Microcrystalline Cellulose. . Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Terms and Conditions Compliance Solutions Industries About 3E News & Events . Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . The table below shows the most common physicochemical parameters of this raw material. Microcrystalline Cellulose (MCC) MSDS 1. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. 51395-75-6 Avicel RC 591. Material safety data sheet - FMC Corporation - YUMPU Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. 4. . Microcrystalline cellulose - Safety Data Sheet - ChemicalBook 2021 Annual Report. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ PDF Material Safety Data Sheet !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Home | FMC Corp More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. A family of polysaccharide products that allow distinctive drug delivery solutions. Medium size standard MCC grade, suited for the majority of directly compressible actives. Micro Crystalline Cellulose - Accent Microcell Pvt. Ltd. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. 9,LL!z /MediaBox [0 0 612 792] ( PDF (28.38 mb) 2022 Corporate Fact Sheet. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. ES454445A1 - Procedimiento para preparar una crema lactica de buena con : 51395-75-6 Date Approved: 01/31/2008 Revision No. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. It is hygroscopic and insoluble in water. PDF PRODUCT OVERVIEW: Avicel RC-591 - Signet /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. xv}O2' H~KEe9>G/,:9\i *r_ *?~4$ &0Y# MCC helps in the formation of spheres because of its . To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. LOT #: Available upon request. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. CAS 9004-34-6, pH 5 - 7.5. Delivering efficient and robust formulations. Global Wood Pulp Based Microcrystalline Cellulose Market - Industry Reports Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. The cellulose molecule is formed through repeated condensation of cellobiose units. Avicel Microcrystalline Cellulose Physical Properties. cas:9032-51-3 msds CELLULOSE PAB. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Characterisation of the interactive properties of microcrystalline AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Alginates also function as actives in some anti-reflux products. }o]X4]. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Gloves, eye protection and a dust mask should be used. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * No. MSDS Ref. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. 2 0 obj ChemicalBook. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. EMCOCEL XLM 90. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. EMCOCEL - JRS Pharma Cellulose, microcrystalline | C14H26O11 - PubChem % cas:9000-11-7 msds Carboxymethyl cellulose. gwf;J(e0o|1p{R~P^);ao!%{0KD7. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Avicel CL-611 Microcrystalline Cellulose and - FMC - YUMPU Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Heavy metals, % NMT 0.001 Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Manufacturer: FMC BioPolymer. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! endstream G2W4de=u183KGH{ vQ#4:1\wc <> Watch Now. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Go to Investor Relations. PDF (4.11 mb) Footer menu 1. MATERIAL SAFETY DATA SHEET. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. SAFETY DATA SHEET - Fisher Sci PROSOLV SMCC - JRS Pharma These, in turn, are assembled into fibrils in the cell wall. Microcrystalline cellulose, a direct compression binder in a quality by Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. In large quantities it provides dietary bulk and may lead to a laxative effect. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. %PDF-1.4 Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . pH 6.0 to 8.0 . PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont
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